Your precision guide to
living longer,
smarter.

Chronological age is the number of years you have lived. Biological age is an estimate of how far your body has aged, calculated from measurements such as standard blood tests or DNA methylation. Researchers have built several of these “clocks”, including PhenoAge, GrimAge and DunedinPACE. They predict health outcomes in research studies, but different clocks can disagree for the same person, and their results do not yet guide treatment. Our Biological Age Calculator includes a PhenoAge calculation from nine standard blood tests, following the published model, and a separate lifestyle questionnaire that is not a validated clock.

The strongest human evidence supports the familiar basics: regular physical activity (higher cardiorespiratory fitness is linked to much lower mortality), resistance training to keep muscle and strength, enough regular sleep, a diet built on whole foods such as the Mediterranean pattern, not smoking, and treating high blood pressure and cholesterol. No drug or supplement is approved to slow aging itself. Drugs such as metformin, rapamycin and GLP-1 agonists are being studied; in 2026, long-term follow-up of the Diabetes Prevention Program found that metformin did not lower the risk of developing multiple chronic diseases, while lifestyle change did. Our Supplement Evidence Database rates the human evidence for 25 supplements and drugs, outcome by outcome.

Start with what guidelines support for adults: a lipid panel (ApoB is a useful addition), a blood sugar test such as HbA1c, kidney and liver function, and a blood count. The 2026 US dyslipidemia guideline also recommends measuring lipoprotein(a) at least once in adulthood. A coronary artery calcium scan is used selectively, when a decision about cholesterol treatment is uncertain. Other markers, such as fasting insulin or hs-CRP, can add information in specific situations. Our lab testing guide explains what to test and when, and the Lab Results Interpreter shows where your results fall against guideline categories.

Yes. Longevity science asks whether an intervention changes health outcomes in people, ideally in randomized trials. Much of what is sold as anti-aging, from face creams to injected peptides and exosome infusions, is marketed on cell or animal studies, testimonials or biomarkers that have not been shown to change outcomes. We label the strength of evidence behind each claim and report negative results as prominently as positive ones: resveratrol, for example, extended life only in mice on a high-calorie diet, and in one trial it blunted the heart benefits of exercise in older men. Our debunked anti-aging claims article covers the most common misconceptions.

Every article cites its sources, each checked against its PubMed or publisher record, and we publish a dated corrections log and explain our methodology in full. Our tools are free; our calculators use published formulas, and our reference tools cite the source behind each range. We do not accept sponsorship from supplement companies, pharmaceutical firms or longevity clinics.

Begin with our Start Here reading path. Our guide to the hallmarks of aging explains the biology, and our articles on VO₂ max and sleep cover two of the best-studied lifestyle factors. Then try the Life’s Essential 8 heart health score in our health calculators section to see where you stand.