Add the supplements, medications, and compounds in your longevity stack. This tool checks for known interactions between them — with severity grades, mechanisms, and cited research.
The longevity community routinely combines multiple supplements, off-label medications, and experimental compounds in pursuit of extended healthspan. Stacks commonly include NMN or NR for NAD+ support, rapamycin for mTOR inhibition, metformin or berberine for AMPK activation, omega-3 fatty acids for inflammation, and a statin for cardiovascular protection. Each compound may be well-studied individually, but the interaction profile of a complex stack is rarely assessed as a whole.
Existing drug interaction checkers — such as those from WebMD, Drugs.com, or Medscape — are designed for pharmaceutical medications and often say little about longevity supplements like NMN, NR, pterostilbene, fisetin or spermidine. For many of these, published interaction data are thin; this tool lists the interactions that have evidence and is explicit about how strong that evidence is.
The Longevity Stack Interaction Checker evaluates pairwise interactions between all compounds in your stack. For each interaction found, it provides a severity grade (high, moderate, low or beneficial), an explanation of the biological mechanism involved, a recommended action, and references to relevant peer-reviewed research. Interactions are categorized by their clinical significance — from potentially dangerous combinations that require medical supervision to synergistic pairings that may enhance effectiveness.
The interactions with the clearest evidence involve absorption and medications: calcium, iron and fiber reduce levothyroxine absorption; calcium reduces iron and zinc absorption; long-term metformin lowers vitamin B12; berberine adds to metformin's glucose-lowering and can raise levels of drugs cleared by CYP3A4; and aspirin adds to warfarin's bleeding risk. The tool currently lists 16 pairwise interactions, each tied to published research.
Every interaction links to the PubMed record of the research behind it, and each entry was checked against those papers (last reviewed October 2026). Where the evidence comes from animals, a single case report or a related drug, the entry says so. Combinations without a listed interaction may simply be unstudied, so absence from this tool is not proof of safety.