120+ evidence-based articles on the science of living longer.
Every article is researched, sourced to peer-reviewed studies, and written for clarity. Browse by category, search by topic, or sort by reading time.
Epigenetic Clocks Explained
How epigenetic clocks estimate biological age from DNA methylation, how the generations of clocks differ, and their limits as a personal test.
Zone 2 Training: Complete Science & Protocol
Zone 2 Training: The Complete Science and Protocol for Metabolic Health and Longevity
The 12 Hallmarks of Aging
The Hallmarks of Aging: A Plain-Language Guide to the 12 Biological Processes Driving Your Decline
NAD+ Precursors: NMN vs NR
NMN vs. NR: The NAD+ Precursor Battle — What the Latest Human Trials Actually Show
Rapamycin and mTOR
The Drug That Extends Lifespan in Yeast, Worms, Flies and Mice
ApoB: The Cholesterol Number Your Doctor Isn't Ordering
ApoB: The Cholesterol Number Your Doctor Probably Is Not Ordering
Sleep and Longevity
Why Sleep Is the Foundation Everything Else Is Built On
Autophagy: How Your Cells Self-Clean
— and Why It Matters for Longevity
Mitochondria and Aging
Why the Decline of Your Cellular Power Plants Is Aging — and What to Do About It
Time-Restricted Eating
A Complete Evidence Review — Benefits, Optimal Windows, and Who It
The Mediterranean Diet for Longevity
What the Strongest Evidence in Nutrition Science Actually Shows
Strength Training for Longevity
What Muscle Strength Predicts and How to Build It
Vitamin D and Longevity
Separating Genuine Benefit from Wishful Thinking
Berberine: Nature's Metformin
Berberine: The Supplement Being Called Nature
VO2 Max Testing
How to Measure Your Cardiorespiratory Fitness
Magnesium: 300 Enzymatic Reactions
Magnesium: The Deficient Mineral at the Center of 300+ Enzymatic Reactions
GLP-1 Agonists and Longevity
Evidence-based guide to GLP-1, GIP, and glucagon receptor agonists for longevity. Semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zep...
Creatine: The Best-Supported Supplement for Muscle Strength
For muscle strength, with resistance training
Metformin for Longevity
The TAME Trial and What We Are Actually Testing
Sauna and Longevity
The Finnish Evidence Behind Heat Therapy
Cold Exposure and Longevity
Ice Baths, Cold Showers, and What the Science Actually Supports
Alzheimer's Prevention
The modifiable risk factors for Alzheimer's disease, how early they start to matter, and the evidence behind exercise, sleep, blood pressure and more.
Heart Rate Variability (HRV)
Heart Rate Variability: The Real-Time Window Into Your Autonomic Nervous System
Grip Strength Predicts Lifespan
Grip Strength: Why Your Handshake Predicts Your Lifespan
Advanced Cardiovascular Testing: CIMT, echocardiography, and coronary CTA beyond the basics
Air Quality and Longevity: The Invisible Environmental Factor Shortening Your Life
Alcohol and Longevity: What the Evidence Actually Shows
AMPK: The Cellular Energy Sensor and What Switches It On
BDNF: What It Does, What Raises It and What Your Levels Mean
Biological Age Testing: Which Epigenetic Clocks Are Worth Using
Blue Zones: What the World's Longest-Lived Populations Actually Have in Common
Blue Zones: What the World
Bone Density and Longevity: Why Your Skeleton Is a Critical Longevity Organ
Bryan Johnson's Blueprint: What It Gets Right, What the Evidence Shows, and What to Actually Take From It
Bryan Johnson
Budget Longevity Protocol: The Evidence-Based Guide to Living Longer for Under $50 Per Month
You don
Caloric Restriction and Longevity: What 90 Years of Research Tells Us About Eating Less
Cancer Screening for Longevity: The Evidence-Based Guide to What to Get and When
Cellular Senescence: What “Zombie Cells” Are and What the Human Evidence Shows
Centenarian Biology: What People Who Live to 100 Actually Have in Common
Chronic Stress, Cortisol, and Aging: The Longevity Cost of Always Being On
Circadian Rhythm and Longevity: How Light, Meal Timing, and Social Jet Lag Age You
Continuous Glucose Monitoring for Non-Diabetics: What Your Blood Sugar Does All Day
CoQ10 and Ubiquinol: Who Actually Needs It and Why
Coronary Artery Calcium Scoring: What Your Score Means and When It Is Used
Depression, Mental Health, and Longevity: The Biological Link Between Mood and Lifespan
Exercise and the Brain: The Neurobiological Case for Moving Your Body
Fasting Insulin and HOMA-IR: The Biomarkers That Catch Metabolic Disease Decades Early
Folate vs Folic Acid: MTHFR, Methylfolate and What the Evidence Shows
Healthy Aging at 70 and Beyond: The Evidence-Based Guide to the Later Decades
HIIT vs Steady-State Cardio: Which Is Better for Longevity
Homocysteine: The Overlooked Cardiovascular and Cognitive Risk Marker
Hormones and Longevity: The Complete Guide to Your Body's Aging Signals
Hormones and Longevity: The Complete Guide to Your Body
HRT for Women: What the Evidence Shows About Hormone Therapy After Menopause
Inflammaging: How Chronic Low-Grade Inflammation Is Linked to Age-Related Disease
Iron Status and Longevity: Why Too Little and Too Much Both Carry Risks
Kidney Health and Longevity: The Organ That Predicts Your Cardiovascular Future
Liver Health and Longevity: Fatty Liver, How It Is Detected and What Helps
Longevity Clinics: What They Offer, What the Evidence Supports, and What to Ask
Longevity Cooking: How to Prepare Food for Maximum Nutritional Density
Longevity for Men: The Male-Specific Aging Timeline and What to Do About It
Longevity for Women: The Evidence-Based Guide to the Female-Specific Aging Timeline
Longevity Genomics: What Your Genes Do and Do Not Determine About Your Lifespan
Longevity Pharmacology: The Complete Drug Review
Longevity Protocol by Age: What to Prioritize in Your 30s, 40s, 50s, and 60s
The right longevity interventions change as you age. This evidence-based guide covers exactly what to prioritize in each decade — testing...
Longevity Protocol with Autoimmune Disease: Evidence-Based Strategies When Your Immune System Works Against You
Autoimmune diseases accelerate aging through chronic inflammation. This guide covers the longevity-specific challenges of autoimmunity — ...
Longevity Protocol with Type 2 Diabetes: The Evidence-Based Guide to Living Longer with Metabolic Disease
Type 2 diabetes accelerates biological aging — but the right interventions can still improve your long-term outlook. This evidence-based g...
Lp(a): The Genetic Cardiovascular Risk Factor Most People Have Never Heard Of
Melatonin: The Sleep Hormone, Its Longevity Biology, and How to Use It Correctly
Metabolic Flexibility: What It Is, How It Is Measured and What Improves It
mTOR: The Master Growth Switch and What Turning It Down Does
Muscle Protein Synthesis: The Science of Building and Preserving Muscle With Age
NAD+, Sirtuins, and Longevity: Separating Genuine Science from Hype
Neuroplasticity Across the Lifespan: How the Brain Rewires Itself and What Drives It
Omega-3 Fatty Acids and Longevity: What Decades of Research Actually Prove
Oral Health and Longevity: The Systemic Consequences of What Happens in Your Mouth
Parkinson's Disease Prevention: What the Evidence Shows About Reducing Your Risk
Parkinson
Peptides for Longevity: BPC-157, TB-500, Sermorelin, and the Evidence Gap That Matters
Peter Attia's Medicine 3.0: The Evidence Behind the Longevity Framework
Peter Attia
Polyphenols and Longevity: The Science Behind Plant Compounds
Prolonged Fasting and the Fasting-Mimicking Diet: The Science of 5-Day Resets
Protein and Longevity: How Much You Actually Need and Why It Changes With Age
Protein Sources for Longevity: Animal vs Plant Protein and How to Choose
Protein Timing: When to Eat Protein for Maximum Muscle and Longevity Benefit
Psychedelic Medicine and Longevity: What the Emerging Research Actually Shows
Sirtuins: The Longevity Genes and What Actually Activates Them
Skin Aging and Longevity: What Your Skin Reveals About Your Biological Age
Sleep Apnea and Longevity: The Health Risks, Diagnosis and What Treatment Does
Sleep Stages and Longevity: Why Deep Sleep and REM Are Non-Negotiable
Sleep Tracking with Wearables: What Your Oura Ring or Whoop Is Actually Measuring
Social Connection and Longevity: The Biology of Belonging
Supplement Brand Testing & Purity Guide: How to Check Third-Party Testing Before You Buy
The supplement industry is unregulated. This guide explains which third-party testing certifications matter, which brands have passed ind...
Supplement Safety: Drug Interactions, Upper Limits, and What to Watch For
Telomeres and Longevity: What They Actually Tell Us - and What They Do Not
Testosterone, Aging, and TRT: What the 2023 TRAVERSE Trial Finally Settled — and What It Didn't
What the TRAVERSE trial found about testosterone therapy and heart risk in men with low testosterone, its limits, and who is a candidate.
The Brain Longevity Blueprint: How to Protect Your Cognitive Health for Life
The Complete Longevity Lab Testing Guide: What to Test, When, and What the Numbers Mean
The Sleep Optimization Guide: The Evidence-Based Strategies in One Place
The Epigenetic Diet: What Food and Lifestyle Can and Cannot Do to Your Genes
The Evidence-Based Longevity Protocol: A Practical Framework for Applying Everything
The Future of Longevity Medicine: What the Next 20 Years Will Bring
The Gut-Brain Axis: How Your Microbiome Shapes Your Mind
The Gut Microbiome Guide: What Shapes It and What the Health Evidence Shows
The Ketogenic Diet and Longevity: What the Evidence Shows Beyond the Hype
The Longevity Exercise Blueprint: The Optimal Protocol for a Longer, Stronger Life
The Longevity Mindset: Purpose, Meaning, and the Biology of Why You Wake Up
The Longevity Nutrients Glossary: Key Micronutrients, What They Do and How Much You Need
The Longevity Nutrition Blueprint: What to Eat, What to Avoid, and Why
The Longevity Supplements Guide: What the Evidence Actually Supports
The State of Longevity Science in 2025: What We Know, What We Are Testing, and What Is Coming
The Top 10 Anti-Aging Claims That Science Has Debunked
The Top 10 Exercise Myths That Are Undermining Your Longevity Protocol
The Wearables Guide: What to Track, What to Ignore, and How to Choose
Thyroid Function and Longevity: What TSH and T4 Tell You, and When Treatment Helps
Uric Acid: The Overlooked Metabolic Biomarker Linking Fructose, Gout, and Cardiovascular Disease
Visceral Fat: The Invisible Longevity Threat Inside Your Abdomen
VO2 Max and Longevity: What Fitness Predicts and How to Improve It
Walking for Longevity: The Underrated Exercise With Remarkable Evidence
Yamanaka Factors and Partial Reprogramming: The Science of Cellular Age Reversal
Zinc and Immune Aging: Why This Mineral Is Critical After 60
Is Red Light Therapy Evidence-Based? The Honest Review
Real mitochondrial biology. Some applications are well-supported. Most longevity claims are not.
Is Methylene Blue the Next Longevity Drug?
Fascinating mitochondrial bypass mechanism. Zero human longevity data. Failed Alzheimer's trials. Real safety concerns.
Does Grounding/Earthing Have Any Evidence?
Grounding mats and earthing sheets: tiny, mostly uncontrolled studies, no sham-controlled sleep trial, weak mechanism. Low risk but overhyped.
Is Hyperbaric Oxygen Worth the Cost?
Hyperbaric oxygen is established medicine for decompression sickness and some wounds. For healthy aging, the evidence is one small trial without a control group.
Do Exosomes Work for Anti-Aging?
Exosome therapy is one of the most expensive and least evidence-based treatments in longevity clinics. The cell biology is real but the clinical evidence for anti-aging is essentially nonexistent. The FDA has issued multiple warnings. Here's the honest review.
Do Longevity Supplements Interact Dangerously?
Berberine + metformin, antioxidants + exercise, NMN + methylation. The interactions nobody talks about.
Long-lived families show a head start that begins in childhood
Wire · May 11, 2026 · A Danish national-registry analysis finds developmental components to exceptional longevity.
FDA greenlights first human trial of partial epigenetic reprogramming
Wire · Apr 30, 2026 · Life Biosciences' ER-100, a Yamanaka-factor therapy, cleared FDA for first-in-human dosing.
FDA pilots real-time clinical trial monitoring
Wire · Apr 28, 2026 · Continuous data review with AstraZeneca and Amgen could compress geroscience trial timelines.
BioAge NLRP3 inhibitor cuts inflammation marker 85% in Phase 1
Wire · Apr 21, 2026 · Oral, brain-penetrant NLRP3 inhibitor dropped median hsCRP by at least 85%.
A nasal spray quiets aging brain inflammation in mice — with caveats
Wire · Apr 14, 2026 · NIA-funded Texas A&M work shows stem-cell EVs reduce neuroinflammaging — but the rejuvenation framing is overcalled.
Stealth biotech pitches "brainless" clones — we think it's a detour
Wire · Mar 30, 2026 · R3 Biotechnologies' "bodyoid" concept and why the longevity community should push back.
The FDA Peptide Reclassification, Explained: What the 2026 Decision Means
The FDA is reversing its 2023 peptide restrictions, with a July 2026 advisory committee vote. Reclassification is not approval — the distinction that reframes the whole story.
Epitalon: The Telomere Peptide — What the Evidence Actually Shows
Marketed as a telomerase-activating longevity peptide. Interesting mechanism, thin and dated human evidence, oversold benefits. An honest review.
MOTS-C: The Mitochondrial Peptide and the Exercise Mimetic Question
A mitochondrial-derived peptide that activates AMPK like exercise and metformin. Promising mechanism, unproven in humans.
DSIP (Delta Sleep-Inducing Peptide): Does It Actually Work?
Its name promises deep sleep; the human evidence is sparse and inconsistent. What DSIP is and why the proven sleep tools are not peptides.
Oral vs transdermal hormone therapy: a nationwide Danish study maps the clot risk
Wire · Oct 4, 2026 · A Danish BMJ study compares clot risk with oral and transdermal menopausal hormone therapy.
Hearing aids in mild cognitive impairment: a two-year trial missed its main goal but found more cognitive improvement
Wire · Oct 4, 2026 · The CHOICE trial of hearing aids in mild cognitive impairment missed its main goal but found more cognitive improvement.
Which exercise protects bone after 40? A review of 124 trials ranks walking, jogging and mixed training
Wire · Oct 4, 2026 · A 124-trial BMJ analysis ranks the exercise that best protects bone density after 40.
The NHS multi-cancer blood test trial missed its main goal. New data show how the test performed
Wire · Oct 4, 2026 · The NHS-Galleri trial did not reduce late-stage cancer diagnoses; new data show the test found about a third of cancers.
MIND diet and brain aging: what a 12-year Framingham study adds, and what it can’t show
Wire · Oct 4, 2026 · A 12-year Framingham study links the MIND diet to slower brain shrinkage; a randomized trial found no difference over three years.
Why semaglutide failed in Alzheimer’s: the trial leaders’ own post-mortem
Wire · Oct 4, 2026 · The EVOKE trials found no benefit from semaglutide in early Alzheimer’s; the trial leaders explain what the data showed.
FDA advisers back six peptides for compounding, reject DSIP
Wire · Sep 30, 2026 · The July committee recommended six peptides for the 503A list, against FDA staff advice. Not binding; none listed yet.
FDA advisory committee to weigh BPC-157 and TB-500 for legal compounding
Wire · Jun 16, 2026 · An FDA panel meets July 23–24 to review seven peptides for the 503A compounding list. Legal supply, not scientific proof.
Longevity Protocol with Fatty Liver Disease
Fatty liver disease (MASLD, formerly NAFLD) affects about 30% of adults worldwide. How weight loss, diet and exercise reduce liver fat, with the trial evidence.
Longevity Protocol with Anxiety & Depression
Anxiety and depression accelerate biological aging through inflammation, cortisol, and behavioral pathways. Evidence-based longevity guide covering exercise, nutrition, supplements, and SSRI interactions.
Longevity Protocol with Heart Disease
Heart disease accelerates biological aging — but evidence-based treatment can still improve your long-term outlook. Complete guide to exercise, testing, supplements, and medications for longevity with cardiovascular risk.
Does Fasting Actually Slow Aging?
Intermittent fasting, time-restricted eating, prolonged fasting, and the fasting-mimicking diet — each has different evidence. We untangle the claims from the science and give you the real picture.
Is Rapamycin Safe for Healthy Humans?
Rapamycin extends mouse lifespan even when started late in life. What the PEARL trial and transplant use show about its safety in healthy adults, and what is unknown.
Longevity Clinics & Services: The Honest Comparison
Honest comparison of longevity clinics, testing services, and concierge medicine — what they cost, what they include, what's evidence-based, and what you can replicate with free tools.
Longevity Protocol with Chronic Kidney Disease
CKD accelerates cardiovascular and biological aging. Evidence-based guide to exercise, nutrition, supplements, and medications for longevity with chronic kidney disease.
Longevity Protocol After Cancer
Cancer treatment accelerates biological aging. Evidence-based guide to exercise, nutrition, testing, and supplements for long-term healthspan after cancer treatment.
Longevity Protocol with ADHD
ADHD medications, dopamine dysregulation, and executive function challenges all affect longevity strategy. Evidence-based guide to optimizing healthspan with attention-deficit/hyperactivity disorder.
Longevity Protocol with Chronic Pain
Chronic pain drives inflammation, inactivity, sleep disruption, and accelerated aging. Evidence-based guide to exercise, nutrition, and supplements for longevity with chronic pain and fibromyalgia.
Longevity Protocol with Thyroid Disorders
Thyroid dysfunction affects metabolism, cardiovascular health, brain function, and biological aging. Evidence-based longevity guide for Hashimoto's, Graves' disease, and hypothyroidism.
Longevity Protocol for Men with Low Testosterone
Low testosterone accelerates aging through muscle loss, metabolic dysfunction, and cardiovascular risk. Evidence-based guide to optimizing testosterone, exercise, and longevity for men.
Longevity Protocol for Post-Menopausal Women
Menopause transforms longevity strategy. Evidence-based guide to HRT decisions, bone density preservation, cardiovascular risk management, and cognitive health for post-menopausal women.
Longevity Protocol with PCOS
PCOS is more than a reproductive condition — it drives metabolic aging, cardiovascular risk, and chronic inflammation. Evidence-based guide to longevity with PCOS covering insulin, exercise, nutrition, and hormone management.