Longevity Protocol
Cost Calculator

How Much Does a Longevity Routine Actually Cost?

Anywhere from nothing to tens of thousands of dollars a year. Tick the items you use or are considering and edit any price to match what you pay: the calculator totals the year, month and day and splits the total by category. Prices are rough estimates entered in early 2026 and not checked against current retailers.

Where the money goes

In this calculator a single supplement costs $12 to $480 a year. The largest items are a concierge clinic membership ($20,000 a year), a self-paid whole-body MRI ($2,500), and testosterone therapy and monthly therapy sessions ($1,800 each).

Price is not evidence

In our Supplement Evidence Database, creatine is rated Supported for muscle strength and lean mass with resistance training, and magnesium for blood pressure (a small effect); the evidence for NMN ($480 a year) is early, from small trials, and spermidine ($420) was not supported in its trial. The "Where your money goes" panel splits your supplement spending by rating as you choose items. Physical activity needs no equipment: US guidelines advise 150 to 300 minutes a week of moderate aerobic activity plus muscle strengthening on 2 or more days.^[1]

How the items are described

Doses are the basis for each price, not advice. Vitamin D is priced at the US RDA of 600 IU a day (800 IU over 70), and the upper limit for adults is 4,000 IU.^[2] Magnesium is priced at up to 350 mg a day, the upper limit for magnesium from supplements.^[3] Carrying an MTHFR variant does not stop folic acid from working (see our folate article), and metformin might reduce vitamin B12 absorption.^[4] Adults are advised to eat 21 to 38 g of fiber a day.^[5]

Medications are in no example bundle: prescription items need a diagnosis and a prescriber. Metformin, rapamycin and acarbose are approved for other uses and unproven for aging. In statin trials, each 1 mmol/L reduction in LDL cholesterol lowered the yearly rate of major vascular events by just over a fifth.^[6] The US Preventive Services Task Force recommends against starting aspirin for prevention at 60 or older and calls it an individual decision at 40 to 59 for people with a 10-year cardiovascular risk of 10% or more.^[7]

Tests. The task force recommends colorectal cancer screening from 45 to 75^[8] and bone-density screening for women 65 and older and for younger postmenopausal women at increased risk.^[9] US cardiology guidelines say a coronary artery calcium scan is reasonable for adults at intermediate risk when a statin decision remains uncertain.^[10] A European consensus panel recommends testing Lp(a) at least once in adulthood.^[11] The American College of Radiology does not recommend whole-body screening for people without symptoms, risk factors or family history, warning of findings that lead to unnecessary follow-up tests.^[12]

Lifestyle. Higher cardiorespiratory fitness was linked to lower long-term mortality in 122,007 adults,^[13] and more frequent sauna use to lower cardiovascular and all-cause mortality in 2,315 Finnish men;^[14] both studies are observational. Among US Medicare beneficiaries, higher outdoor fine-particle (PM2.5) pollution was linked to higher mortality.^[15] A Cochrane review found blue-light-filtering glasses may not reduce eye strain, with uncertain effects on sleep.^[16] The evidence on low-dose lithium is observational: more lithium in Danish drinking water was linked to less dementia, but other local factors could not be ruled out.^[17]