Category

Research and Clinics

24 evidence-based articles

Longevity headlines often run ahead of the evidence, and the exaggeration frequently starts before the news story. In a study of 462 press releases from 20 leading UK universities, 40% contained exaggerated advice, 33% exaggerated causal claims and 36% exaggerated inference from animals to humans; news stories were far more likely to exaggerate when the press release did.1

Even influential findings do not always hold up. Of 45 highly cited clinical studies that reported an intervention worked, 7 were later contradicted and 7 more had reported stronger effects than later studies found; nonrandomized studies fared worst.2 That is why this section follows trials designed to test aging directly, such as TAME, designed to test metformin as a first step toward drugs that target aging itself.3

The articles below weigh popular frameworks and protocols, longevity clinics and the research frontier against that standard.

Reading path

Read in this order: the essentials first, then the detail, then the reviews that test popular claims.

Start here

  1. The Evidence-Based Longevity Protocol: A Practical Framework for Applying EverythingA practical framework that turns the site's research into a weekly routine for exercise, sleep, nutrition, testing and supplements.
  2. The Top 10 Anti-Aging Claims That Science Has DebunkedTen popular anti-aging claims checked against the research, why they caught on, and what the evidence actually shows instead.

Go deeper

  1. Longevity Clinics: What They Offer, What the Evidence Supports, and What to AskWhat longevity clinics typically offer, which tests and treatments have evidence behind them, and the questions to ask before you pay.
  2. Peter Attia's Medicine 3.0: The Evidence Behind the Longevity FrameworkThe ideas behind Peter Attia's Medicine 3.0, from the four horsemen to fitness as medicine, and how well the evidence supports each one.
  3. Bryan Johnson's Blueprint: What It Gets Right, What the Evidence Shows, and What to Actually Take From ItA look at Bryan Johnson's Blueprint protocol: which parts rest on solid evidence, which are speculative, and what is practical for most people.
  4. The Future of Longevity Medicine: What the Next 20 Years Will BringWhere longevity medicine may go in the next two decades, from aging drugs and biomarkers to reprogramming, and which trials to watch.

Evidence checks

  1. Is Hyperbaric Oxygen Worth the Cost? What the Evidence ShowsHyperbaric oxygen is established medicine for decompression sickness and some wounds. For healthy aging, the evidence is one small trial without a control group.
  2. Do Exosomes Work for Anti-Aging?Exosome therapy is one of the most expensive and least evidence-based treatments in longevity clinics. The cell biology is real but the clinical evidence for anti-aging is essentially nonexistent. The FDA has issued multiple warnings. Here's the honest review.

Sources

  1. 1Sumner P, et al. "The association between exaggeration in health related science news and academic press releases: retrospective observational study." BMJ. 2014;349:g7015. PubMed · DOI
  2. 2Ioannidis JP. "Contradicted and initially stronger effects in highly cited clinical research." JAMA. 2005;294(2):218-28. PubMed · DOI
  3. 3Barzilai N, et al. "Metformin as a Tool to Target Aging." Cell Metab. 2016;23(6):1060-1065. PubMed · DOI
Start Here
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